Modification of cell-surface thiols elicits activation of human monocytic cell line THP-1: possible involvement in effect of haptens 2,4-dinitrochlorobenzene and nickel sulfate.

@article{Hirota2009ModificationOC,
  title={Modification of cell-surface thiols elicits activation of human monocytic cell line THP-1: possible involvement in effect of haptens 2,4-dinitrochlorobenzene and nickel sulfate.},
  author={Morihiko Hirota and Mie Suzuki and Shigenobu Hagino and Saori Kagatani and Yoshinori Sasaki and Setsuya Aiba and Hiroshi Itagaki},
  journal={The Journal of toxicological sciences},
  year={2009},
  volume={34 2},
  pages={139-50}
}
Human monocytic cell line THP-1 cells are used as an indicator for in vitro skin sensitization testing. Although p38 mitogen-activated protein kinases (MAPKs) and intracellular redox imbalance play crucial roles in the activation of THP-1 by skin sensitizers, the trigger of cell activation has not been identified. Therefore, we examined whether haptens… CONTINUE READING