Modification of carotid chemoreceptor-induced changes in renal haemodynamics and function by carotid baroreflex in dogs.

@article{Karim1993ModificationOC,
  title={Modification of carotid chemoreceptor-induced changes in renal haemodynamics and function by carotid baroreflex in dogs.},
  author={Fadzlina Karim and M al-Obaidi},
  journal={The Journal of physiology},
  year={1993},
  volume={466},
  pages={599-610}
}
1. Mongrel dogs were anaesthetized with thiopental sodium and chloralose and artificially ventilated. The carotid sinus regions were vascularly isolated and perfused either with arterial or mixed (arterial and venous) blood (PO2, 44.2 +/- 3.3 mmHg, mean +/- S.E.M.) to stimulate the chemoreceptors. Cervical vagosympathetic trunks were ligated and atenolol (2 mg kg-1, I.V.) was given in all dogs and gallamine triethiodide (3 mg kg-1 h-1, I.V.) was given in two dogs. Renal blood flow was measured… CONTINUE READING