Modification of biophysical properties of lung epithelial Na(+) channels by dexamethasone.

@article{Lazrak2000ModificationOB,
  title={Modification of biophysical properties of lung epithelial Na(+) channels by dexamethasone.},
  author={Ahmed Lazrak and Arabinda Samanta and Kiriaki Venetsanou and Pascal Barbry and Shabtay Matalon},
  journal={American journal of physiology. Cell physiology},
  year={2000},
  volume={279 3},
  pages={C762-70}
}
There is considerable interest in identifying the basic mechanisms by which dexamethasone alters ion transport across the adult alveolar epithelium. Herein, we incubated synchronized A549 cells, a human alveolar epithelial cell line, with dexamethasone (1 microM) for 24-48 h. When normalized to HPRT (a housekeeping gene), A549 beta- and gamma-subunit mRNA levels for the human amiloride-sensitive epithelial sodium channel (hENaC), assessed by RT-PCR, increased by 1.6- and 17-fold respectively… CONTINUE READING
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