Modification of beta-2-microglobulin in sera from patients with small cell lung cancer: evidence for involvement of a serine protease.

@article{Nissen1987ModificationOB,
  title={Modification of beta-2-microglobulin in sera from patients with small cell lung cancer: evidence for involvement of a serine protease.},
  author={Mogens Holst Nissen and Ole Jannik Bjerrum and Torben Plesner and Martin Wilken and Mikael Rahbek R\orth},
  journal={Clinical and experimental immunology},
  year={1987},
  volume={67 2},
  pages={425-32}
}
Modification of beta-2-microglobulin has been shown to occur in vitro in serum of patients suffering of small cell lung cancer, where it clearly correlated to the clinical course of disease. The cause of serum beta-2-microglobulin modification occurring in these patients is investigated in the present study. This revealed that modification of beta-2-microglobulin is due to cleavage by a serine protease, which is dependent on divalent cations and has a trypsin-like specificity. The process… CONTINUE READING

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