Modification of actions of heat shock on development and apoptosis of cultured preimplantation bovine embryos by oxygen concentration and dithiothreitol

@article{deCastroePaula2008ModificationOA,
  title={Modification of actions of heat shock on development and apoptosis of cultured preimplantation bovine embryos by oxygen concentration and dithiothreitol},
  author={L A de Castro e Paula and Peter James Hansen},
  journal={Molecular Reproduction and Development},
  year={2008},
  volume={75}
}
Preimplantation embryos exposed to elevated temperatures have reduced developmental competence. The involvement of reactive oxygen species in these effects has been controversial. Here we tested hypotheses that (1) heat shock effects on development and apoptosis would be greater when embryos were cultured in a high oxygen environment (air; oxygen concentration = ∼20.95%, v/v) than in a low oxygen environment (5% oxygen) and (2) that these effects would be reversed by addition of the antioxidant… 
View on Wiley
animal.ifas.ufl.edu
35 Citations
Highly Influential Citations
1
Background Citations
14
Methods Citations
3

35 Citations

Citation Type

Citation Type

Consequences of physiological heat shock beginning at the zygote stage on embryonic development and expression of stress response genes in cattle.
TLDR
Examination of cell numbers at 72 hpi indicated that heat shock reduced developmental potential of embryos by reducing competence to complete cleavage divisions after first cleavage.
Cellular and molecular basis of therapies to ameliorate effects of heat stress on embryonic development in cattle
TLDR
There are indications that pregnancy rates can be improved by feeding supplemental β-carotene or administration of melatonin implants and involvement of reactive oxygen species in actions of elevated temperature on embryo survival is indicative that provision of antioxidants to heat-stressed cows could improve fertility.
Effect of physiologically relevant heat shock on development, apoptosis and expression of some genes in buffalo (Bubalus bubalis) embryos produced in vitro.
TLDR
It is demonstrated that exposure of buffalo oocytes and embryos to elevated temperatures for duration of time that is physiologically relevant severely compromises their developmental competence, increases apoptosis and affects stress-, apoptosis- and development-related genes.
Involvement of free cholesterol and high-density lipoprotein in development and resistance of the preimplantation bovine embryo to heat shock.
TLDR
Raising cholesterol content does not improve embryonic survival in response to heat shock and high density lipoprotein is thermoprotective to embryos and probably acts through a mechanism independent of its actions on embryonic content of free cholesterol.
Modification of embryonic resistance to heat shock in cattle by melatonin and genetic variation in HSPA1L.
TLDR
It was concluded that lack of effect of melatonin or oxygen concentration on embryonic development means that the negative effects of heat shock on the zygote are not mediated by ROS, and previously reported effect ofMelatonin on fertility of heat-stressed cows might involve actions independent of the antioxidant properties ofmelatonin.
Cellular and epigenetic changes induced by heat stress in bovine preimplantation embryos
TLDR
The effects of elevated temperature on the bovine embryo is characterized, especially addresissing developmental, cellular, and epigenetic alterations triggered in response to temperature.
Effects of folic acid on the development and oxidative stress of mouse embryos exposed to heat stress.
TLDR
The results indicate that the mRNA of folate-methionine cycle enzymes are expressed in mouse pre-implantation embryos, suggesting they can independently utilize folate, and the inhibitory effects of heat stress on the development of mousePre-im implantation embryos are ameliorated by folic acid.
Developmental changes in thermoprotective actions of insulin-like growth factor-1 on the preimplantation bovine embryo
Melatonin slightly alleviates the effect of heat shock on bovine oocytes and resulting blastocysts.
Developmental changes in thermoprotective actions of insulin-like growth factor-1 on the preimplantation bovine embryo
TLDR
Treatment of embryos with 100 ng/ml IGF1 reduced the effects of heat shock on embryos ≥16 cells at day 5 after insemination but did not provide thermoprotection to two-cell embryos.
...
1
2
3
4
...

References

SHOWING 1-10 OF 48 REFERENCES
Actions of thermal stress in two-cell bovine embryos: oxygen metabolism, glutathione and ATP content, and the time-course of development.
TLDR
The finding that heat shock causes a block to development at the eight-cell stage implies that previously reported mitochondrial damage caused by heat shock or other heat shock-induced alterations in cellular physiology render the embryo unable to proceed past the eight -cell stage.
Developmental changes in sensitivity of bovine embryos to heat shock and use of antioxidants as thermoprotectants.
TLDR
Early bovine embryos are susceptible to disruption in development caused by heat shock, and as embryos progress in development, they acquire resistance to heat shock.
Heat Shock-Induced Apoptosis in Preimplantation Bovine Embryos Is a Developmentally Regulated Phenomenon1
TLDR
In conclusion, apoptosis is a developmentally acquired phenomenon that occurs in embryos exposed to elevated temperature, and it can be prevented by induced thermotolerance.
Response of preimplantation murine embryos to heat shock as modified by developmental stage and glutathione status
TLDR
Development changes in response to heat shock in the preimplantation mouse embryo were generally minimal, but 2-cell embryos delayed in development had reduced thermal resistance, and therefore, maternal heat stress may be more likely to cause mortality of embryos that are already compromised in development.
Developmental changes in inhibitory effects of arsenic and heat shock on growth of pre‐implantation bovine embryos
TLDR
In conclusion, arsenic can compromise development of bovine pre‐implantation embryos, the temporal window of sensitivity of embryos to arsenic is wider than for heat shock, and cellular cytoprotective responses that embryos acquire for thermal resistance are not sufficient to cause increased embryonic resistance to arsenic exposure.
Effects of heat shock on in vitro development and intracellular oxidative state of bovine preimplantation embryos
TLDR
The results indicate that heat shock to earlier stage embryos causes a decrease in development to blastocysts and cell proliferation and the decrease by heat shock could be involved in an increase of intracellular oxidative stress.
Apoptosis is an adaptive response in bovine preimplantation embryos that facilitates survival after heat shock.
Differential responses of bovine oocytes and preimplantation embryos to heat shock
TLDR
Results indicate there is a biphasic change in resistance to elevations in temperature as oocytes mature, become fertilized, and develop and evidence suggests a role for cumulus cells in increasing HSP70 molecules and protein synthesis.
Effects of purple sweet potato anthocyanins on development and intracellular redox status of bovine preimplantation embryos exposed to heat shock.
TLDR
It is shown that alterations of the redox state using natural antioxidative polyphenols is a useful approach for reducing heat shock-derived oxidative stress in heat-exposed bovine preimplantation embryos by reducing intracellular oxidative stress and increasing the GSH levels.
Developmental competence and oxidative state of mouse zygotes heat-stressed maternally or in vitro.
TLDR
It is demonstrated that maternal heat stress at the zygote stage reduces the developmental ability of mouse embryos via physiological changes in the maternal environment that lead to an increase in intracellular oxidative stress on the embryo.
...
1
2
3
4
5
...