Modification of T cell receptor beta chain gene: the J2 region but not the J1 region of the T cell receptor beta chain gene is hypomethylated in human B cells and monocytes.

Abstract

In order to determine the relationship between the generation of a 1.0 kb mRNA and methylation of the T cell receptor beta chain gene, we have analyzed the methylation state of the T cell receptor beta chain gene (T beta) in monocyte and B cell DNA, focusing on the J1 and J2 regions of this gene in human genomic DNA. We have observed that a portion of the… (More)

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@article{Sakamoto1988ModificationOT, title={Modification of T cell receptor beta chain gene: the J2 region but not the J1 region of the T cell receptor beta chain gene is hypomethylated in human B cells and monocytes.}, author={S. Sakamoto and H. A. Young}, journal={Nucleic acids research}, year={1988}, volume={16 5}, pages={2149-63} }