Modification of Microbial Polymalic Acid With Hydrophobic Amino Acids for Drug-Releasing Nanoparticles.

@article{LanzLandzuri2012ModificationOM,
  title={Modification of Microbial Polymalic Acid With Hydrophobic Amino Acids for Drug-Releasing Nanoparticles.},
  author={Alberto Lanz-Land{\'a}zuri and Montserrat Garc{\'i}a-Alvarez and Jos{\'e} Portilla-Arias and Antxon Mart{\'i}nez de Ilarduya and Eggehard Holler and Julia Y. Ljubimova and Sebasti{\'a}n Mu{\~n}oz-Guerra},
  journal={Macromolecular chemistry and physics},
  year={2012},
  volume={213 15},
  pages={1623-1631}
}
Microbial poly(β, l-malic acid) was modified with either l-leucine ethyl ester (L) or l-phenylalanine methyl ester (F) to produce amphiphylic copolymers. The degradation of these copolymers in aqueous buffer took place under physiological conditions in a few weeks by hydrolysis of the side chain ester group followed by cleavage of the main chain. Spherical nanoparticles with diameters ranging between 70 and 230 nm were prepared from these copolymers by the dialysis-precipitation method. No… CONTINUE READING
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