Modification of Cardiac Progenitor Cell-Derived Exosomes by miR-322 Provides Protection against Myocardial Infarction through Nox2-Dependent Angiogenesis

@inproceedings{Youn2019ModificationOC,
  title={Modification of Cardiac Progenitor Cell-Derived Exosomes by miR-322 Provides Protection against Myocardial Infarction through Nox2-Dependent Angiogenesis},
  author={Seock-Won Youn and Yang Li and Young-Mee Kim and Varadarajan Sudhahar and Kareem Abdelsaid and Ha Won Kim and Yutao Liu and David J. R. Fulton and Muhammad Ashraf and Yaoliang Tang and Tohru Fukai and Masuko Ushio-Fukai},
  booktitle={Antioxidants},
  year={2019}
}
Myocardial infarction (MI) is the primary cause of cardiovascular mortality, and therapeutic strategies to prevent or mitigate the consequences of MI are a high priority. Cardiac progenitor cells (CPCs) have been used to treat cardiac injury post-MI, and despite poor engraftment, they have been shown to inhibit apoptosis and to promote angiogenesis through poorly understood paracrine effects. We previously reported that the direct injection of exosomes derived from CPCs (CPCexo) into mouse… CONTINUE READING
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