Modification of CD4 immunoadhesin with monomethoxypoly(ethylene glycol) aldehyde via reductive alkylation.

@article{Chamow1994ModificationOC,
  title={Modification of CD4 immunoadhesin with monomethoxypoly(ethylene glycol) aldehyde via reductive alkylation.},
  author={Steven M. Chamow and Timothy P. Kogan and Marco Venuti and Thomas R Gadek and Richard J. Harris and D H Peers and Joyce J Mordenti and S Shak and Avi Ashkenazi},
  journal={Bioconjugate chemistry},
  year={1994},
  volume={5 2},
  pages={133-40}
}
CD4 immunoadhesin (CD4-IgG) is a chimeric glycoprotein molecule comprised of the gp120-binding portion of human CD4 fused to the hinge and Fc portions of human IgG. As a candidate for human therapeutic use, CD4-IgG represents an important advance over soluble CD4, insofar as the systemic clearance in humans of CD4-IgG is significantly slower. In an effort to prolong its in vivo residence time even further, we have modified CD4-IgG chemically by attaching monomethoxypoly(ethylene glycol) (MePEG… CONTINUE READING