Modification by yohimbine and prazosin of the mechanical response of isolated dog mesenteric, renal and coronary arteries to transmural stimulation and norepinephrine.

Abstract

Some functions of pre- and postsynaptic alpha-receptors were compared in isolated dog arteries. In mesenteric and renal arteries, contractile responses to transmural electrical stimulation were potentiated by yohimbine, a selective alpha 2-antagonist; the potentiation was greater in mesenteric arteries. Concentration-response curves for norepinephrine were… (More)

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