Modification by indomethacin of the blood pressure lowering effect of pindolol and propranolol in conscious rabbits.

@article{Duro1977ModificationBI,
  title={Modification by indomethacin of the blood pressure lowering effect of pindolol and propranolol in conscious rabbits.},
  author={Virg{\'i}lio Dur{\~a}o and Jos{\'e} Luis Montoya Rico},
  journal={European journal of pharmacology},
  year={1977},
  volume={43 4},
  pages={
          377-81
        }
}
In conscious rabbits, the intravenous administration of pindolol (0.125 mg/kg) and propranolol (1 mg/kg) induced a highly significant (p less than 0.001) decrease of mean arterial blood pressure and with propranolol, a significant (p less than 0.01) bradycardia. In the same model the intravenous administrtion of saline (1 ml/kg) and of indomethacin (1 mg/kg) did not affect mean arterial blood pressure or heart rate (p greater than 0.3). Pretreatment of the animals with indomethacin (1 mg/kg… CONTINUE READING
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