Modification by ageing of the tetrodotoxin-sensitive sodium channels in rat skeletal muscle fibres.

@article{Desaphy1998ModificationBA,
  title={Modification by ageing of the tetrodotoxin-sensitive sodium channels in rat skeletal muscle fibres.},
  author={Jean-François Desaphy and Antonella De Luca and Paola Imbrici and Diana Conte Camerino},
  journal={Biochimica et biophysica acta},
  year={1998},
  volume={1373 1},
  pages={37-46}
}
Ageing leads to an impairment of muscle performance that may result from alteration of sarcolemma excitability. Therefore, we compare sodium channels of native fast-twitch skeletal muscle fibres of 21-26-month-old aged rats and 4-6-month-old young-adult rats, using the patch-clamp method. Extrajunctional sarcolemma of aged-rat fibres presented a higher… CONTINUE READING