Modification by Islet‐Activating Protein of Direct and Indirect Inhibitory Actions of Adenosine on Rat Atrial Contraction in Relation to Cyclic Nucleotide Metabolism

@article{Endoh1983ModificationBI,
  title={Modification by Islet‐Activating Protein of Direct and Indirect Inhibitory Actions of Adenosine on Rat Atrial Contraction in Relation to Cyclic Nucleotide Metabolism},
  author={Masao Endoh and Masahiko Maruyama and Norio Taira},
  journal={Journal of Cardiovascular Pharmacology},
  year={1983},
  volume={5},
  pages={131–142}
}
Summary Adenosine decreased the force of contraction of isolated rat left atria (direct action) and inhibited the positive inotropic action of isoproterenol (indirect action). The direct action of adenosine was not accompanied by changes in cyclic nucleotide levels, while the isoproterenol-induced increase in cyclic AMP level was reduced by the nucleoside. Reserpine pretreatment and pindolol did not affect the direct action of adenosine. Both the direct and indirect actions of adenosine were… 

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  • 1987
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