Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine, quinidine, and loperamide following oral administration in collies.

@article{Kitamura2008ModestEO,
  title={Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine, quinidine, and loperamide following oral administration in collies.},
  author={Yoshiaki Kitamura and Hisao Koto and Shinobu Matsuura and Takeshi Kawabata and Hiroshi Tsuchiya and Hiroyuki Kusuhara and Hajime Tsujimoto and Yuichi Sugiyama},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2008},
  volume={36 5},
  pages={807-10}
}
P-glycoprotein (P-gp), encoded by the multidrug resistance 1 gene (MDR1/ABCB1), exhibits very broad substrate specificity and plays important roles in drug disposition. The purpose of the present study was to examine the effect of impaired P-gp activity on the plasma pharmacokinetics of P-gp substrates in collies with or without homozygous mutant alleles producing truncated P-gp. Three therapeutic agents, fexofenadine (0.1 mg/kg), quinidine (0.1 mg/kg), and loperamide (0.01 mg/kg), were… CONTINUE READING