Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria.

@article{Benton2008ModestPO,
  title={Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria.},
  author={Carley R. Benton and James G. Nickerson and James S. V. Lally and Xiao-xia Han and Graham P Holloway and Jan F. C. Glatz and Joost J. F. P. Luiken and Terry E. Graham and John J. Heikkila and Arend Bonen},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 7},
  pages={4228-40}
}
PGC-1alpha overexpression in skeletal muscle, in vivo, has yielded disappointing and unexpected effects, including disrupted cellular integrity and insulin resistance. These unanticipated results may stem from an excessive PGC-1alpha overexpression in transgenic animals. Therefore, we examined the effects of a modest PGC-1alpha overexpression in a single rat muscle, in vivo, on fuel-handling proteins and insulin sensitivity. We also examined whether modest PGC-1alpha overexpression selectively… CONTINUE READING
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