Modes of spread of cancer of skin.

@article{Mohs1952ModesOS,
  title={Modes of spread of cancer of skin.},
  author={Frederic E. Mohs and Theodore G. Lathrop},
  journal={A.M.A. archives of dermatology and syphilology},
  year={1952},
  volume={66 4},
  pages={
          427-39
        }
}
  • F. Mohs, T. G. Lathrop
  • Published 1 October 1952
  • Medicine, Biology
  • A.M.A. archives of dermatology and syphilology
DURING the past sixteen years more than three thousand cancers have been removed by means of the microscopically controlled excisions which characterize the method which we have termed "chemosurgery." 1 A striking observation repeatedly made during the course of these excisions was that many external cancers exhibited irregular outgrowths which had not been detected by clinical visualization and palpation. In some cases these "silent" extensions were due to a peculiar affinity of the cancer for… 
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144 Citations
Highly Influential Citations
4
Background Citations
19
Methods Citations
2

144 Citations

Microscopically controlled surgery in the treatment of carcinoma of the scalp.
TLDR
The reliability of this technique is demonstrated by the treatment results obtained in a series of 576 basal cell carcinomas, where the cure rate for the 444 patients who were observed for five years or longer was 98.9%.
Epidermoid carcinoma of the skin involving the parotid gland.
Chemosurgery for the microscopically controlled excision of skin cancer
  • F. Mohs
  • Medicine
    Proceedings. National Cancer Conference
  • 1970
TLDR
Advantages of the method are unprecedented reliability, conservatism, low operative mortality, excellent healing, and the fact that it extends operability to many patients with cancers too extensive for hope of cure by other methods.
Treatment of Cutaneous Squamous Cell Carcinoma with Perineural Invasion Using Mohs Micrographic Surgery: Report of Two Cases and Review of the Literature
TLDR
Unpredictable tumor spread along the loose connective tissue of the perineurium allows the movement of single tumor cells away from the bulk of the tumor proximally and distally, making histologic identification and complete excision difficult.
Microscopically controlled surgery in the treatment of carcinoma of the penis.
The role of Mohs' micrographic surgery in the management of skin cancer and a perspective on the management of the surgical defect.
  • J. Lang
  • Medicine
    Clinics in plastic surgery
  • 2004
Management of periocular basal cell carcinoma: Mohs' micrographic surgery versus radiotherapy.
MOHS MICROGRAPHIC SURGERY: TECHNIGAL DIFFICULTIES POSED BY PERINEURAL INVASION
TLDR
Perineural invasion is particularly problematic in tumors of the head and neck due to the extensive nervous supply to this region and the number and types of tumors found there.
Perineural spread of cutaneous squamous cell carcinoma via the orbit. Clinical features and outcome in 21 cases.
Chemosurgery for facial neoplasms.
  • F. Mohs
  • Medicine
    Archives of otolaryngology
  • 1972
TLDR
The microscopic control permits selective removal of "silent" outgrowths from the main cancerous mass the method achieves unprecedented reliability without the need to sacrifice an extra margin of normal tissue.
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References

SHOWING 1-10 OF 18 REFERENCES
CHEMOSURGERY: A MICROSCOPICALLY CONTROLLED METHOD OF CANCER EXCISION
TLDR
This paper presents a method for the treatment of carcinoma which is localized to an accessible region of the body, and it does not give the answer as to the cause of cancer, nor does it eliminate surgical intervention or radium or roentgen therapy in the Treatment of the disease.
Chemosurgical treatment of cancer of the skin; a microscopically controlled method of excision.
  • F. Mohs
  • Medicine
    Journal of the American Medical Association
  • 1948
TLDR
The chemosurgical method was devised to provide a microscopically controlled means for the excision of various accessible forms of cancer and offers certain important advantages, including unprecedented reliability and conservatism.
Chemosurgical treatment of cancer of the ear; a microscopically controlled method of excision.
TLDR
The present article concerns the chemosurgical treatment of cancer of the skin except for the orificial cancers affecting the lips, vulva, penis and anus.
Chemosurgical treatment of cancer of the nose; a microscopically controlled method.
  • F. Mohs
  • Medicine
    Archives of surgery
  • 1946
TLDR
The present article concerns the chemosurgical treatment of cancer of the nose, including the therapeutic results, in a series of two hundred and forty-three lesions treated over a nine year period.
Chemosurgical treatment of cancer of the extremities and trunk; a microscopically controlled method of excision.
  • F. Mohs
  • Medicine
    Archives of surgery
  • 1948
TLDR
The present article concerns the technic used and the therapeutic results obtained in the treatment of cancer of the extremities and trunk and the chemosurgical technic will be described by means of the report of a case ofcancer of the thumb.
Chemosurgical treatment of cancer of the face; a microscopically controlled method of excision.
  • F. Mohs
  • Medicine
    Archives of dermatology and syphilology
  • 1947
TLDR
This article concerns the chemosurgical treatment of cancer of the face, exclusive of the nose, ear, eyelid and vermilion portion of the lips.
Chemosurgery in cutaneous malignancy.
TLDR
With microscopic examination of each layer of tissue removed, it is possible to avoid removing more than one or two millimeters of healthy tissue beyond the extent of the cancer.
Spreading factor in human carcinomas.
TLDR
Experiments were designed to answer the question: is there evidence that human malignant tunmrs contain a spreading factor, such as hyaluronidase, which hydrolyses the connective tissue constituent hyaluronic acid.
Visualization of the movement of a brominized oil along peripheral nerves
The Action of Tumor Extracts on the Spread of Experimental Vaccinia of the Rabbit
TLDR
There is a special factor contained in the germinal cells which is responsible for the potent enhancing action of testis, epididymis, and sperm, and this factor is not species specific, is very stable, and is capable of being purified to a high degree.
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