Modes of salmonid MHC class I and II evolution differ from the primate paradigm.

@article{Shum2001ModesOS,
  title={Modes of salmonid MHC class I and II evolution differ from the primate paradigm.},
  author={Benny P. Shum and Libby Guethlein and Laura R. Flodin and Mark A. Adkison and Ronald P. Hedrick and Ramlah B. Nehring and Ren{\'e} J. M. Stet and Christopher J Secombes and Peter Parham},
  journal={Journal of immunology},
  year={2001},
  volume={166 5},
  pages={3297-308}
}
Rainbow trout (Oncorhynchus mykiss) and brown trout (Salmo trutta) represent two salmonid genera separated for 15--20 million years. cDNA sequences were determined for the classical MHC class I heavy chain gene UBA and the MHC class II beta-chain gene DAB from 15 rainbow and 10 brown trout. Both genes are highly polymorphic in both species and diploid in expression. The MHC class I alleles comprise several highly divergent lineages that are represented in both species and predate genera… CONTINUE READING
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