Modes of physiologic H2S signaling in the brain and peripheral tissues.

Abstract

SIGNIFICANCE Hydrogen sulfide (H2S), once associated with rotten eggs and sewers, is now recognized as a gasotransmitter that is synthesized in vivo in a regulated fashion. This ancient gaseous molecule has been retained throughout evolution to perform various roles in different life forms. H2S modulates important signaling functions in diverse cellular… (More)
DOI: 10.1089/ars.2014.5917

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