Modes of operation and variable stoichiometry of the furosemide- sensitive Na and K fluxes in human red cells.

@article{Canessa1986ModesOO,
  title={Modes of operation and variable stoichiometry of the furosemide- sensitive Na and K fluxes in human red cells.},
  author={M Aurora Canessa and Carlo Brugnara and Daniele Cusi and Daniel C. Tosteson},
  journal={The Journal of general physiology},
  year={1986},
  volume={87 1},
  pages={113-42}
}
We report in this paper different modes of Na and K transport in human red cells, which can be inhibited by furosemide in the presence of ouabain. Experimental evidence is provided for inward and outward coupled transport of Na and K, Ki/Ko and Nai/Nao exchange, and uncoupled Na or K efflux. The outward cotransport of Na and K was defined as the furosemide-sensitive (FS) component of Na and K effluxes into choline medium and as the Cl-dependent or cis-stimulated component of the ouabain… CONTINUE READING

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