Modes of neuronal migration in the developing cerebral cortex

  title={Modes of neuronal migration in the developing cerebral cortex},
  author={Bagirathy Nadarajah and John G. Parnavelas},
  journal={Nature Reviews Neuroscience},
The conventional scheme of cortical formation shows that postmitotic neurons migrate away from the germinal ventricular zone to their positions in the developing cortex, guided by the processes of radial glial cells. However, recent studies indicate that different neuronal types adopt distinct modes of migration in the developing cortex. Here, we review evidence for two modes of radial movement: somal translocation, which is adopted by the early-generated neurons; and glia-guided locomotion… 
Neuronal migration in the developing cerebral cortex: observations based on real-time imaging.
A unique morphological and migratory behavior for a population of cortical neurons, found to originate in the ganglionic eminence, which is multipolar in form, and are highly motile in the formation and retraction of their processes is reported.
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
Neuronal migration and the role of reelin during early development of the cerebral cortex
Three aspects are placed on the role of the actin treadmill, with cyclic formation of filopodial and lamellipodial extensions, in relation to surface events that occur at the leading edge of radially migrating neurons; the regulation of microtubule dynamics, which seems to play a key role in nucleokinesis; and the mechanisms by which the extracellular protein Reelin regulates neuronal positioning at the end of migration.
Transcriptional regulation of tangential neuronal migration in the developing forebrain
In vivo evidence for radial migration of neurons by long-distance somal translocation in the developing ferret visual cortex.
In vivo and in vitro evidence is provided for the existence of late-born cortical neurons that migrate radially by long-distance somal translocation within a long apical process extended to the cortical plate, in contrast to the early soma translocation observed in rodents.
Cell and molecular mechanisms involved in the migration of cortical interneurons
Results of very recent analyses of the underlying cellular mechanisms and specifically of the movement of the nucleus, cytoplasmic components and neuritic processes during interneuron migration are reviewed.
Multidirectional and multizonal tangential migration of GABAergic interneurons in the developing cerebral cortex
Time-lapse imaging and in vivo labelling indicated that MZ cortical interneurons undergo a second phase of tangential migration in all directions and over long distances, after reaching the cortex by dorsomedial tangential Migration.


Two modes of radial migration in early development of the cerebral cortex
It is demonstrated, using time-lapse imaging of acute cortical slices, that two distinct forms of cell movement, locomotion and somal translocation, are responsible for the radial migration of cortical neurons.
Diverse migratory pathways in the developing cerebral cortex.
Time-lapse confocal microscopy was used to observe directly the dynamic behaviors of migrating cells in living slices of developing cortex, and the majority of cells migrated along a radial pathway, consistent with the view that cortical neurons migrate along radial glial fibers.
Ventricle-directed migration in the developing cerebral cortex
Using time-lapse imaging of brain slices, populations of neurons positioned at various levels of the developing neocortex that migrate towards the cortical ventricular zone are found, suggesting combinations of chemoattractant and chemorepellent molecules are involved in this ventricle-directed migration.
The origin and migration of cortical neurones: new vistas
Neuronal migration, with special reference to developing human brain: a review.
A long, remarkable journey: Tangential migration in the telencephalon
Evidence that supports the existence of several tangential migration pathways in the telencephalon is reviewed, and recent findings that describe their regulation are summarized.
Central nervous system neuronal migration.
  • M. Hatten
  • Biology
    Annual review of neuroscience
  • 1999
Molecular analysis of the genes that mark stages of secondary neurogenesis show similar expression patterns of a number of genes, so these three regions may have genetic pathways in common and be considered for human brain malformations and neurological mutant mice.
LIS1 and dynein motor function in neuronal migration and development.
Several recent studies have demonstrated that LIS1, the protein product of a gene mutated in the human neuronal migration defect lissencephaly, binds to and regulates dynein motor function in the cell, which place LIS 1 in the midst of a well-studied motor complex important for several critical cell functions and perhaps provide a context for integrating several neuronal migration pathways.