Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence

@inproceedings{Carpentier2015ModesOH,
  title={Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence},
  author={Antoine F Carpentier and Pierre-Yves Barez and Malik Hamaidia and H{\'e}l{\`e}ne Gazon and Alix de Brogniez and Srikanth Perike and Nicolas Gillet and Luc Willems and David D. Boehr},
  booktitle={Viruses},
  year={2015}
}
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy-tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying an integrated provirus. After transcription, the viral genomic RNA undergoes reverse transcription and integration into the chromosomal DNA of a cell from the newly… CONTINUE READING
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