Modern molecular cytogenetic techniques in genetic diagnostics.

  title={Modern molecular cytogenetic techniques in genetic diagnostics.},
  author={Holger Toennies},
  journal={Trends in molecular medicine},
  volume={8 6},
During the past decade, fluorescence in situ hybridization (FISH) has become an important complementing application in genetic diagnostics. The use of variable FISH techniques enhances the thorough interpretation of numerical and complex chromosome aberrations, bridging the gap between conventional chromosome banding analysis and molecular genetic DNA studies. This review gives a brief overview of the different molecular cytogenetic FISH techniques and applications currently used in routine… CONTINUE READING
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