Modern management of chronic granulomatous disease.

  title={Modern management of chronic granulomatous disease.},
  author={Reinhard A. Seger},
  journal={British journal of haematology},
  volume={140 3},
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder of phagocytic cells resulting in failure to kill a characteristic spectrum of bacteria and fungi and in defective degradation of inflammatory mediators with concomitant granuloma formation. Current prophylaxis with trimethoprim-sulfamethoxazole, itraconazole and in selected cases additional interferon gamma is efficient, but imperfect. A significant recent progress towards new antibiotic (e.g. linezolid) and… CONTINUE READING


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