Pigmentary disorders (melanoses) has various clinical manifestations. Melanoses are classified on the basis of their origin (congenital and acquired; primary and secondary), spread area (local and generalized), and skin discoloration (hypermelanoses, hypomelanoses, and amelanoses). Vitiligo is the most frequent disease among hypomelanoses. Vitiligo patients have depigmentation maculi, the histological analysis of which shows either the absence of or a dramatic decrease in the content of melanin. The prevalence of this dermatosis is 1–2% in the Caucasoid population, which is 3 to 4% of all known dermatoses . In recent years, the interest in this problem increased, because the vitiligo pathogenesis is presumably related to that of cutaneous melanoma. However, the mechanisms leading to vitiligo are still insufficiently understood, though comprehensive studies are being performed in this field. Numerous factors account for the vitiligo development, including stress and genetic, neuroendocrinal, biochemical, and immune mechanisms (see the scheme).