Moderation of adult depression by the serotonin transporter promoter variant (5‐HTTLPR), childhood abuse and adult traumatic events in a general population sample

@article{Grabe2012ModerationOA,
  title={Moderation of adult depression by the serotonin transporter promoter variant (5‐HTTLPR), childhood abuse and adult traumatic events in a general population sample},
  author={H. Grabe and C. Schwahn and J. Mahler and A. Schulz and C. Spitzer and Kristin Fenske and K. Appel and S. Barnow and M. Nauck and G. Schomerus and R. Biffar and D. Rosskopf and U. John and H. V{\"o}lzke and H. Freyberger},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2012},
  volume={159B}
}
The impact of the promoter polymorphisms of the serotonin transporter (5‐HTTLPR) on mood has been studied by two‐way interaction models comprising one environmental factor and genotype variants. However, childhood abuse is assumed to be associated with different psychobiological long‐term effects than adult traumatic events. Both types of trauma may interact on an individual basis throughout the lifespan moderating the impact of the 5‐HTTLPR s allele on depressive disorders. Therefore, the… Expand
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  • Eva Reinelt, S. Barnow, +4 authors H. Grabe
  • Psychology, Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2015
Testing the diathesis‐stress model: 5‐HTTLPR, childhood emotional maltreatment, and vulnerability to social anxiety disorder
The 5-HTTLPR polymorphism and posttraumatic stress disorder: a meta-analysis.
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