Moderate sodium restriction in hypertensive subjects: renal effects of ACE-inhibition.

@article{Navis1987ModerateSR,
  title={Moderate sodium restriction in hypertensive subjects: renal effects of ACE-inhibition.},
  author={Gerjan J. Navis and Paul E de Jong and Ab J M Donker and G K van der Hem and Dick de Zeeuw},
  journal={Kidney international},
  year={1987},
  volume={31 3},
  pages={
          815-9
        }
}
It has been suggested that AII-mediated renal mechanisms limit the efficacy of moderate sodium restriction in the lowering of blood pressure (BP) in hypertension. We therefore studied renal hemodynamics and sodium handling in nine essential hypertensives in balance on 200 and on a 50 mmol sodium diet, before and during ACE-inhibition (enalapril 10 mg bid for 8 days) in a cross-over fashion. BP was similar on 50 and 200 mmol Na before enalapril, the fall in BP during enalapril was significantly… CONTINUE READING
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