Moderate inhibition of mitochondrial function augments carotid body hypoxic sensitivity

@article{Holmes2015ModerateIO,
  title={Moderate inhibition of mitochondrial function augments carotid body hypoxic sensitivity},
  author={Andrew P Holmes and Philip J. Turner and Keith J Buckler and Prem Kumar},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2015},
  volume={468},
  pages={143-155}
}
A functional role for the mitochondria in acute O2 sensing in the carotid body (CB) remains undetermined. Whilst total inhibition of mitochondrial activity causes intense CB stimulation, it is unclear whether this response can be moderated such that graded impairment of oxidative phosphorylation might be a mechanism that sets and modifies the O2 sensitivity of the whole organ. We assessed NADH autofluorescence and [Ca2+]i in freshly dissociated CB type I cells and sensory chemoafferent… CONTINUE READING
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