Moderate hypothermia in severe head injuries: the present and the future.

@article{Marion2002ModerateHI,
  title={Moderate hypothermia in severe head injuries: the present and the future.},
  author={Donald W. Marion},
  journal={Current opinion in critical care},
  year={2002},
  volume={8 2},
  pages={111-4}
}
The use of therapeutic moderate hypothermia for treating severe traumatic brain injury has been reported for more than 50 years. However, the most intense investigation of this treatment has occurred during the last 10 to 15 years. Virtually all preclinical studies have documented a robust treatment effect, not only in terms of reduced excitotoxicity and cerebral acidosis, but also in terms of histologic preservation and improved behavioral outcomes. Several single-center and small multicenter… CONTINUE READING

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