Moderate hypothermia attenuates α(1)-adrenoceptor-mediated contraction in isolated rat aorta: the role of the endothelium.

@article{Chung2012ModerateHA,
  title={Moderate hypothermia attenuates α(1)-adrenoceptor-mediated contraction in isolated rat aorta: the role of the endothelium.},
  author={Jin-Young Chung and Jung Eun Kim and Hyuk-Jun Yoon and Seok-Young Song and Si-Oh Kim and Woon-Seok Roh},
  journal={Cryobiology},
  year={2012},
  volume={65 1},
  pages={
          33-40
        }
}
Moderate hypothermia (25-31 °C) may have a significant influence on vascular tone. We investigated the cellular mechanisms by which moderate hypothermia alters α-adrenoceptor-mediated contraction in rat thoracic aortae. Cyclooxygenase inhibition by indomethacin; nitric oxide (NO) synthase inhibition by L-NAME; potassium channel and endothelium-derived hyperpolarizing factor (EDHF) inhibition by glibenclamide and TEA; G protein inhibition by pertussis toxin; α₂-adrenergic inhibition by yohimbine… CONTINUE READING