Moderate hyperglycemia augments ischemic brain damage: a neuropathologic study in the rat.

@article{Pulsinelli1982ModerateHA,
  title={Moderate hyperglycemia augments ischemic brain damage: a neuropathologic study in the rat.},
  author={William A. Pulsinelli and Stuart Waldman and Donald G. Rawlinson and Fred Plum},
  journal={Neurology},
  year={1982},
  volume={32 11},
  pages={
          1239-46
        }
}
We compared the effects of glucose injection with those of saline or mannitol on ischemic brain damage and brain water content in a four-vessel occlusion (4-VO) rat model, which simultaneously causes severe forebrain ischemia and moderate hindbrain ischemia. Glucose given before onset of ischemia was followed by severe brain injury, with necrosis of the majority of neocortical neurons and glia, substantial neuronal damage throughout the remainder of forebrain, and severe brain edema. By… CONTINUE READING
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