1,693 Citations
MILD TRAUMATIC BRAIN INJURY UPDATE
- MedicineContinuum
- 2010
Treatment for mild TBI are rather diverse, and early intervention is the key to maximizing outcomes following a TBI, and topics and more will be discussed throughout this article.
Traumatic Brain Injury: Current Management, Controversies, and Clinical Trials
- Medicine
- 2011
O Ongoing and future trials in TBI should be conducted using the best possible methodologies to avoid the clinical futility found in past trials of promising therapies.
Moderate and Severe Traumatic Brain Injury
- MedicineContinuum
- 2021
This article reviews TBI in neurocritical care, hence focusing on moderate and severe TBI, and includes an up-to-date review of the many variables to be considered in clinical care.
Traumatic brain injury: an evidence-based review of management
- Medicine
- 2013
Almost one-third of patients who die after a TBI will talk or obey commands before their death, and factors such as hypoxia, hypotension, and alcohol intoxication can all affect GCS, leading to diagnostic confusion.
Recent Advances and Future Trends in Traumatic Brain Injury
- Medicine
- 2015
Scientific understanding of the problem in its various dimensions, complexities and controversies regarding diagnostic and therapeutic modalities, outcome and impact of TBIs on rapidly transforming societies, challenges and opportunities in research and linking research to practice are addressed.
Biomarkers of Traumatic Brain Injury in the Geriatric Population
- MedicineCurrent Translational Geriatrics and Experimental Gerontology Reports
- 2012
This review highlights some of the latest technology that may pave the way for advanced diagnostic and treatment modalities in TBI management and identifies specific markers of brain cell damage that may offer insight to the nature and progression of injury.
End Points of Traumatic Brain Injury Resuscitation
- MedicineCurrent Trauma Reports
- 2015
The role of clinical assessment, as such the Glasgow Coma Scale and the Full Outline of UnResponsiveness Score, neuroimaging, including computed tomography and MRI, and current research innovations, such as the biomarkers, to predict TBI outcomes are discussed.
Traumatic brain injury in humans and animal models
- Biology
- 2012
The genetic polymorphisms of BDNF predict general intelligence following penetrating TBI, and the importance of categorizing the different types of TBI is shown, not only through the use of animal models but also in the clinical setting.
Rodent Models of Traumatic Brain Injury: Methods and Challenges.
- BiologyMethods in molecular biology
- 2016
In this chapter, the methods, limitations, and challenges of the CCI and FPI models of TBI used in rodents are described.
Severe Traumatic Brain Injury
- MedicineContinuum
- 2012
The guidelines for management of patients with severe TBI are summarized along with outcome measures and insight into some novel physiologic monitoring devices available are offered.
References
SHOWING 1-10 OF 195 REFERENCES
Clinical trials in head injury.
- MedicineJournal of neurotrauma
- 2002
This workshop proved to be very informative and yielded many insights into previous and future TBI trials, and it is hoped that these lessons will enhance the planning and design of future efforts in this important field of research.
Intracranial hypertension and cerebral perfusion pressure: Influence on neurological deterioration and outcome in severe head injury.:
- Medicine
- 2000
Examination of the relationship and relative importance of ICP and CPP in severely head injured patients is examined by examining the higher risk group who manifest neurological deterioration following initial resuscitation after admission to the hospital.
Prognosis and clinical trial design in traumatic brain injury: the IMPACT study.
- MedicineJournal of neurotrauma
- 2007
The IMPACT database on TBI is created through merging individual patient data from eight RCTs and three observational surveys, and it is hypothesized that the statistical power of TBI trials may be increased by adjusting for heterogeneity with covariate adjustment and/or prognostic targeting.
The European Brain Injury Consortium Survey of Head Injuries
- MedicineActa Neurochirurgica
- 1999
Comparisons of the data from different parts of Europe showed substantial similarities and also differences that may reflect variations in policy for admission of the head injury to `neuro' units, and evolution in methods of assessment, investigation and management.
Epidemiology of traumatic brain injury in South Australia.
- MedicineBrain injury
- 1997
It was apparent that hospitals in this state care for more than 4000 new cases of TBI each year and that, on discharge, over 1000 of these will have some degree of residual impairment and will therefore require some form of post-injury services.
Systematic review of prognostic models in traumatic brain injury
- Medicine, PsychologyBMC Medical Informatics Decis. Mak.
- 2006
Prognostic models for TBI are frequently published but they are developed from small samples of patients, their methodological quality is poor and they are rarely validated on external populations, which means the generalizability to these setting is limited.
Coagulation disorders after traumatic brain injury
- MedicineActa Neurochirurgica
- 2007
It is concluded that coagulopathy following traumatic brain injury is an important independent risk factor related to prognosis and routine determination of the coagulation status should therefore be performed in all patients withtraumatic brain injury.
Outcome of traumatic brain injuries in 1,508 patients: impact of prehospital care.
- MedicineJournal of neurotrauma
- 2002
Results from the 1,508 patients treated in a single neurosurgical unit over an 8-year period show that outcome for the severely injured patients in the present study is more favorable than in other large series of TBI.
The role of surgery in traumatic brain injury
- MedicineCurrent opinion in critical care
- 2007
A surgical approach is frequent in posttraumatic intracranial hematomas in spite of a low level of evidence and one of the surgical options either in association with hematoma evacuation or in isolation is the technique of bone flap decompression.