Moderate, chronic ethanol feeding exacerbates carbon tetrachloride–induced hepatic fibrosis via hepatocyte-specific hypoxia-inducible factor 1α


The hypoxia-sensing transcriptional factor HIF1α is implicated in a variety of hepato-pathological conditions; however, the contribution of hepatocyte-derived HIF1α during progression of alcoholic liver injury is still controversial. HIF1α induces a variety of genes including those involved in apoptosis via p53 activation. Increased hepatocyte apoptosis is… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.


Citations per Year

125 Citations

Semantic Scholar estimates that this publication has 125 citations based on the available data.

See our FAQ for additional information.

Slides referencing similar topics