Models of the cooperative mechanism for Rho effector recognition: implications for RhoA-mediated effector activation.

@article{Blumenstein2004ModelsOT,
  title={Models of the cooperative mechanism for Rho effector recognition: implications for RhoA-mediated effector activation.},
  author={Lars Blumenstein and Mohammad Reza Ahmadian},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 51},
  pages={53419-26}
}
Activated GTPases of the Rho family regulate a spectrum of functionally diverse downstream effectors, initiating a network of signal transduction pathways by interaction and activation of effector proteins. Although effectors are defined as proteins that selectively bind the GTP-bound state of the small GTPases, there have been also several indications for a nucleotide-independent binding mode. By characterizing the molecular mechanism of RhoA interaction with its effectors, we have determined… CONTINUE READING

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