Models of neurodegenerative disease - Alzheimer's anatomical and amyloid plaque imaging.

  title={Models of neurodegenerative disease - Alzheimer's anatomical and amyloid plaque imaging.},
  author={Alexandra Petiet and Benoit Delatour and Marc Dhenain},
  journal={Methods in molecular biology},
Alzheimer's disease (AD) is an important social and economic issue for our societies. The development of therapeutics against this severe dementia requires assessing the effects of new drugs in animal models thanks to dedicated biomarkers. According to the amyloid cascade hypothesis, β-amyloid deposits are at the origin of most of the lesions associated with AD. These extracellular deposits are therefore one of the main targets in therapeutical strategies. Aβ peptides can be revealed… CONTINUE READING
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