Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): a critical discussion.

@article{Ingawale2014ModelsOH,
  title={Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): a critical discussion.},
  author={Deepa Krushna Ingawale and Satish Karbhari Mandlik and Suresh Ramnath Naik},
  journal={Environmental toxicology and pharmacology},
  year={2014},
  volume={37 1},
  pages={118-33}
}
Liver is a primary organ involved in biotransformation of food and drugs. Hepatic diseases are a major worldwide problem. Hepatic disorders are mainly caused by toxic chemicals (alcohol), xenobiotics (carbon tetrachloride, chlorinated hydrocarbons and gases CO₂ and O₂) anticancer (azathioprine, doxorubicin, cisplatin), immunosuppressant (cyclosporine), analgesic anti-inflammatory (paracetamol, thioacetamide), anti-tubercular (isoniazid, rifampicin) drugs, biologicals (Bacillus-Calmette-Guerin… CONTINUE READING

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