Models of hepatic drug clearance: discrimination between the 'well stirred' and 'parallel-tube' models.

@article{Ahmad1983ModelsOH,
  title={Models of hepatic drug clearance: discrimination between the 'well stirred' and 'parallel-tube' models.},
  author={Ali Ahmad and Peter N. Bennett and Malcolm Rowland},
  journal={The Journal of pharmacy and pharmacology},
  year={1983},
  volume={35 4},
  pages={219-24}
}
The predictive ability of two models of hepatic drug clearance are compared. The 'parallel-tube' model predicts that the steady-state drug concentration following constant rate oral administration increases with increase in hepatic blood flow. The 'well-stirred' model predicts that this parameter is not sensitive to changes in hepatic blood flow. Using the… CONTINUE READING