Models of carcinogenesis: an overview.

@article{Vineis2010ModelsOC,
  title={Models of carcinogenesis: an overview.},
  author={Paolo Vineis and Arthur S Schatzkin and John D. Potter},
  journal={Carcinogenesis},
  year={2010},
  volume={31 10},
  pages={1703-9}
}
At least five coherent models of carcinogenesis have been proposed in the history of cancer research in the last century. Model 1 is mainly centered around mutations, and its main focus is on the chemical environment, radiation and viruses. Model 2 has to do mainly with genome instability and it focuses on familiality. Model 3 is based on non-genotoxic mechanisms, and clonal expansion and epigenetics are its main features. We propose a fourth model, which can encompass the previous three, based… CONTINUE READING
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