Models of carcinogenesis: an overview.

  title={Models of carcinogenesis: an overview.},
  author={Paolo Vineis and Arthur S Schatzkin and John D. Potter},
  volume={31 10},
At least five coherent models of carcinogenesis have been proposed in the history of cancer research in the last century. Model 1 is mainly centered around mutations, and its main focus is on the chemical environment, radiation and viruses. Model 2 has to do mainly with genome instability and it focuses on familiality. Model 3 is based on non-genotoxic mechanisms, and clonal expansion and epigenetics are its main features. We propose a fourth model, which can encompass the previous three, based… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
43 Citations
69 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 43 extracted citations


Publications referenced by this paper.
Showing 1-10 of 69 references

Molecular mechanisms of differential intracellular signaling from the insulin receptor

  • D. M. Muoio
  • Vitam . Horm .
  • 2009

Epigenetics in cancer

  • R. A. Waterland
  • N . Engl . J . Med .
  • 2008

Mechanisms of disease : molecular and metabolic mechanisms of insulin resistance and beta - cell failure in type 2 diabetes

  • N. Musi
  • Nat . Rev . Mol . Cell Biol .
  • 2008

Radiation carcinogenesis : lessons from Chernobyl

  • M. P. Little
  • Oncogene
  • 2008

Similar Papers

Loading similar papers…