Models of blood coagulation.

  title={Models of blood coagulation.},
  author={Kenneth G. Mann and Kathleen E. Brummel-Ziedins and Thomas Orfeo and Saulius Butenas},
  journal={Blood cells, molecules & diseases},
  volume={36 2},
Our research aims to provide quantitatively transparent, biologically realistic descriptions of the processes involved in hemostasis which will permit predictions of the behavior of the coagulation system in normal and pathologic states. We use four models of coagulation: (1) numerical approximations of the tissue factor (Tf) pathway of thrombin generation based upon mechanism and dynamics; (2) Tf activation of the "blood coagulation proteome" from isolated cells and proteins; (3) Tf activated… CONTINUE READING