Models of affective illness: chronic mild stress in the rat.

@article{Papp2012ModelsOA,
  title={Models of affective illness: chronic mild stress in the rat.},
  author={Mariusz Papp},
  journal={Current protocols in pharmacology},
  year={2012},
  volume={Chapter 5},
  pages={Unit 5.9.}
}
Described in this unit is a chronic mild stress (CMS) procedure used for predicting an antidepressant response. Following exposure to a variety of mild stressors for a period of several weeks, rat behavior is modified in a number of ways. Among these is a substantial reduction in consumption of a 1% sucrose solution. Chronic administration of antidepressant drugs reverses diminished enthusiasm for sucrose in these subjects. While most antidepressants must be administered for at least 3 to 5… CONTINUE READING

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