Models for thiol protection of DNA in cells.

  title={Models for thiol protection of DNA in cells.},
  author={Kathryn D Held},
  journal={Pharmacology & therapeutics},
  volume={39 1-3},
It is generally assumed that death of a cell from exposure to ionizing radiation results primarily from damage to DNA, although the exact relationship between the two endpoints is not clear. Furthermore, the relationship between modification of DNA damage by the addition of thiols and modification of cell killing is not understood. Various models have been used to study DNA damage and the effects of thiols on it. These include studies of radiation chemistry of DNA constituents, physical damage… CONTINUE READING

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