Models for the study of Clostridium difficile infection

@article{Best2012ModelsFT,
  title={Models for the study of Clostridium difficile infection},
  author={Emma L. Best and Jane Freeman and Mark H. Wilcox},
  journal={Gut Microbes},
  year={2012},
  volume={3},
  pages={145 - 167}
}
Models of Clostridium difficile infection (C. difficile) have been used extensively for Clostridium difficile (C. difficile) research. The hamster model of C. difficile infection has been most extensively employed for the study of C. difficile and this has been used in many different areas of research, including the induction of C. difficile, the testing of new treatments, population dynamics and characterization of virulence. Investigations using in vitro models for C. difficile introduced the… 
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103 Citations
Highly Influential Citations
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103 Citations

Small animal models for the study of Clostridium difficile disease pathogenesis.
TLDR
This review summarises key aspects of the small animal models currently used in C. difficile studies with a specific focus on major differences between them and highlights the advantages and disadvantages of each model.
Murine models to study Clostridium difficile infection and transmission.
Mixed infection by Clostridium difficile in an in vitro model of the human gut.
TLDR
Data suggest that multiple C. difficile strains are able to proliferate concurrently in an in vitro model reflective of the human colon, which augments recent human epidemiological studies in this area.
Predictive values of models of Clostridium difficile infection.
Clostridium difficile infection
Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life threatening, especially in elderly people and in patients who have dysbiosis of the gut microbiota…
Dynamics and Establishment of Clostridium difficile Infection in the Murine Gastrointestinal Tract
TLDR
An integrated understanding of the timing and location of the events surrounding C. difficile colonization is provided and potential targets for the development of new therapeutic strategies are identified.
Effect of antibiotic to induce Clostridioides difficile-susceptibility and infectious strain in a mouse model of Clostridioides difficile infection and recurrence
Clostridium difficile Drug Pipeline: Challenges in Discovery and Development of New Agents
TLDR
The current drug discovery pipeline is reviewed, including both small molecule and biologic therapies, and highlights the challenges associated with in vitro and in vivo models of C. difficile infection for drug screening and lead optimization.
In silico Analysis of Clostridium difficile Biofilm Metabolism and Treatment
Successional Dynamics in the Gut Microbiome Determine the Success of Clostridium difficile Infection in Adult Pig Models
TLDR
The observed community patterns suggest that successional dynamics following antibiotic treatment facilitate C. difficile establishment, and the similarities between the microbiome responses observed in this study and those reported in CDI-infected humans further support the utility of adult pigs as models for the study of CDI.
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References

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TLDR
Since 2001, the prevalence and severity of C. difficile infection has increased significantly, which has led to increased research interest and the discovery of new virulence factors, and has expanded and focused the development of new treatment and prevention regimens.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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