Models for male infertility: the t haplotypes.

@article{OldsClarke1997ModelsFM,
  title={Models for male infertility: the t haplotypes.},
  author={Patricia Olds-Clarke},
  journal={Reviews of reproduction},
  year={1997},
  volume={2 3},
  pages={
          157-64
        }
}
The t haplotypes are variant alleles of genes in the proximal region of mouse Chromosome 17, linked together by four inversions. While females carrying two t haplotypes are fertile, males are sterile. Their spermatozoa exhibit severe motility defects and are unable to penetrate zona pellucida-free oocytes. Spermatozoa from males carrying one t haplotype (t/+) exhibit mild motility deficits and a delay in penetration of the zona-free oocyte. The inversions of the t haplotypes contain several… CONTINUE READING

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