Models for clinical assessment of oral analgesics.

  title={Models for clinical assessment of oral analgesics.},
  author={Stephen A. Cooper},
  journal={The American journal of medicine},
  volume={75 5A},
Renewed interest in analgesic models has been stimulated by the development of several new nonsteroidal anti-inflammatory drugs. Many of these new analgesic agents appear to have higher peak effects and longer durations of action than acetylsalicylic acid. Sensitive models are necessary to determine the dose-effect relationships and relative analgesic efficacies of these new agents. The basic principles of clinical methods--double-blinding, identical appearance of study medications, and random… CONTINUE READING