Models for Assessment of Angiogenesis in Gliomas

  title={Models for Assessment of Angiogenesis in Gliomas},
  author={Roland Goldbrunner and Sven Wagner and Klaus Roosen and J. -C. Tonn},
  journal={Journal of Neuro-Oncology},
In the last two decades, much attention has been focussed on mechanisms of glioma vascularization including the investigation of growth factors and receptors involved. Recently, these efforts resulted in various approaches for antiangiogenic treatment of experimental brain tumors. These basic science and preclinical trials need an assortment of models, which should allow investigating a variety of questions. Several objectives concerning basic endothelial cell (EC) characteristics can… CONTINUE READING
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