Models and Mechanisms of Acquired Antihormone Resistance in Breast Cancer: Significant Clinical Progress Despite Limitations.

@article{Sweeney2012ModelsAM,
  title={Models and Mechanisms of Acquired Antihormone Resistance in Breast Cancer: Significant Clinical Progress Despite Limitations.},
  author={Elizabeth E. Sweeney and Russell E. McDaniel and Philipp Y. Maximov and Ping Fan and V. Craig Jordan},
  journal={Hormone molecular biology and clinical investigation},
  year={2012},
  volume={9 2},
  pages={143-163}
}
Translational research for the treatment and prevention of breast cancer depends upon the four Ms: models, molecules, and mechanisms in order to create medicines. The process, to target the estrogen receptor (ER) in estrogen-dependent breast cancer, has yielded significant advances in patient survivorship and the first approved medicines (tamoxifen and raloxifene) to reduce the incidence of any cancer in high- or low-risk women. This review focuses on the critical role of the few ER-positive… CONTINUE READING
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