Modelling within-Host Spatiotemporal Dynamics of Invasive Bacterial Disease

  title={Modelling within-Host Spatiotemporal Dynamics of Invasive Bacterial Disease},
  author={Andrew J Grant and Olivier Restif and Trevelyan J. McKinley and Mark Sheppard and Duncan J Maskell and Pietro Mastroeni},
  journal={PLoS Biology},
  pages={327 - 332}
Mechanistic determinants of bacterial growth, death, and spread within mammalian hosts cannot be fully resolved studying a single bacterial population. They are also currently poorly understood. Here, we report on the application of sophisticated experimental approaches to map spatiotemporal population dynamics of bacteria during an infection. We analyzed heterogeneous traits of simultaneous infections with tagged Salmonella enterica populations (wild-type isogenic tagged strains [WITS]) in… CONTINUE READING
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