Modelling the response of spatially structured tumours to chemotherapy: Drug kinetics

@article{Norris2006ModellingTR,
  title={Modelling the response of spatially structured tumours to chemotherapy: Drug kinetics},
  author={E. S. Norris and John R. King and Helen M. Byrne},
  journal={Mathematical and Computer Modelling},
  year={2006},
  volume={43},
  pages={820-837}
}
In this paper we consider the effects of a single anticancer agent on the growth of a solid tumour in the context of a simple mathematical model for the latter. The tumour is assumed to comprise a single cell population which reproduces and dies at a rate dependent on the local drug concentration. This causes cell movement and so establishes a velocity field within the tumour. We investigate the action of a single chemotherapeutic drug on the tumour and explore how different drug kinetics and… CONTINUE READING

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