## The role of spatial variations of abiotic factors in mediating intratumour phenotypic heterogeneity.

- Tommaso Lorenzi, Chandrasekhar Venkataraman, Alexander Lorz, Mark A. J. Chaplain
- Journal of theoretical biology
- 2018

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@article{Norris2006ModellingTR, title={Modelling the response of spatially structured tumours to chemotherapy: Drug kinetics}, author={E. S. Norris and John R. King and Helen M. Byrne}, journal={Mathematical and Computer Modelling}, year={2006}, volume={43}, pages={820-837} }

- Published 2006 in Mathematical and Computer Modelling
DOI:10.1016/j.mcm.2005.09.026

In this paper we consider the effects of a single anticancer agent on the growth of a solid tumour in the context of a simple mathematical model for the latter. The tumour is assumed to comprise a single cell population which reproduces and dies at a rate dependent on the local drug concentration. This causes cell movement and so establishes a velocity field within the tumour. We investigate the action of a single chemotherapeutic drug on the tumour and explore how different drug kinetics and… CONTINUE READING