Modelling the pH-dependent properties of Kv1 potassium channels.

  title={Modelling the pH-dependent properties of Kv1 potassium channels.},
  author={Binbin Liu and David R. Westhead and Mark R. Boyett and Jim Warwicker},
  journal={Journal of molecular biology},
  volume={368 2},
It is known that the pH dependence of conductance for the rat potassium channel Kv1.4 is susbstantially reduced upon mutation of either H508 or K532. These residues lie in the extracellular mouth of the channel pore. We have used continuum electrostatics to investigate their interactions with K(+) sites in the pore. The predicted scale of interactions between H508/K532 and potassium sites is sufficient to significantly alter potassium occupancy and thus channel function. We interpret the effect… CONTINUE READING

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