Modelling the onset of senescence at the G1/S cell cycle checkpoint

  title={Modelling the onset of senescence at the G1/S cell cycle checkpoint},
  author={Jos{\'e} C. M. Mombach and Cristhian Augusto Bugs and Claudine Chaouiya},
  booktitle={BMC Genomics},
DNA damage (single or double-strand breaks) triggers adapted cellular responses. These responses are elicited through signalling pathways, which activate cell cycle checkpoints and basically lead to three cellular fates: cycle arrest promoting DNA repair, senescence (permanent arrest) or cell death. Cellular senescence is known for having a tumour-suppressive function and its regulation arouses a growing scientific interest. Here, we advance a qualitative model covering DNA damage response… CONTINUE READING
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