Corpus ID: 89827387

Modelling the multi-step process of tumorigenesis in pigs

@inproceedings{Saalfrank2015ModellingTM,
  title={Modelling the multi-step process of tumorigenesis in pigs},
  author={Anja Saalfrank},
  year={2015}
}
  • Anja Saalfrank
  • Published 2015
  • Biology
  • The pig has gained much interest as an alternative animal model for human cancers due to its shared anatomical and physiological characteristics with humans. This work describes the neoplastic transformation of stepwise genetically modified porcine mesenchymal stem cells (MSCs) in vitro. Expression of oncogenic p53 and Kras in combination with p16INK4α gene silencing and deregulated cMyc expression resulted in immortalised, transformed porcine MSCs. Several in vitro and in vivo assays confirmed… CONTINUE READING

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